Publications

Full pulblication list in ORCID, Google Scholar, and PubMed

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Most recent conference abtracts

2024

• H Ni, N Khorasani, Y Wu, S Morotti, D Dobrev, E Grandi. Computational modeling identifies increased background Ca2+ influx as a potential promoter of arrhythmogenic Ca2+ instability in atrial fibrillation. Biophysical Journal 123 (3), 384a, 2024
• NT Herrera, H Ni, C Smith, D Dobrev, S Morotti, E Grandi. In silico investigation of sex-specific atrial electrophysiologic mechanisms and arrhythmia vulnerability. Biophysical Journal 123 (3), 192a, 2024
• N Khorasani, H Ni, D Dobrev, E Grandi. Revealing key mechanisms of atrial fibrillation-associated fibrosis through computational modeling of cardiac fibroblast. Biophysical Journal 123 (3), 278a 2024
• Y Wu, X Zhang, WE Louch, MA Colman, H Ni, E Grandi. Unveiling sex-specific mechanisms of atrial Ca2+ dysregulation and Ca2+-driven arrhythmia via multiscale modeling. Biophysical Journal 123 (3), 383a, 2024
• R Shetty, S Morotti, V Sobota, JD Bayer, H Ni, E Grandi. Translating electrocardiogram features across sexes. Biophysical Journal 123 (3), 458a. 2024

2023

• H Ni, X Zhang, Y Wu, D Lang, S Morotti, AV. Glukhov, E Grandi. 3D spatial modeling of sinoatrial node cells reveals a critical role of subcellular ryanodine receptor distribution in pacemaker automaticity. Biophysical Society 67th Annual Meeting, February 18-22, 2023

• X Zhang, Y Wu, C Smith, S Morotti, E Grandi, H Ni. Modeling sex differences in human atrial myocyte structural and ca2+ handling properties: impact on ca2+-driven arrhythmia. Biophysical Society 67th Annual Meeting, February 18-22, 2023

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Preprints and Manuscripts Under Review

• Zhang X, Wu Y, Smith C, Louch WE, Morotti S, Dobrev D, Grandi E#, Ni H#. Enhanced Ca2+-Driven Arrhythmias in Female Patients with Atrial Fibrillation: Insights from Computational Modeling. bioRxiv. 2024. doi:10.1101/2024.03.04.583217
• Lang D, Ni H, Liu F, Medvedev R, Turner D, Warden A, Lim E, Morotti S, Rickert C, Lodin R, Proenza C, Kamp T, Robertson G, Grandi E, Glukhov A. Caveolar Compartmentalization is Required for Stable Rhythmicity of Sinus Nodal Cells and is Disrupted in Heart Failure. bioRxiv. 2024. https://doi.org/10.1101/2024.04.14.589457
• W Xiang, L Li, M Qin*, L Li, H Yu, F Wang, S Ni, A Shen, H Lu, H Ni#, Y Wang#. Diminished Nuclear-localized β-adrenergic signaling activates YAP to promote kidney fibrosis in diabetic nephropathy. (In Revision with BJP)
• CE.R. Smith#, H Ni, E Grandi#. Sex Differences in Electrophysiology and Calcium Handling in Atrial Health and Fibrillation. (Invited review article for Annual Review of Physiology)
• L Reilly, M Josvai, M Kalluri, CL. Anderson, H Ni, KM. Orland, D Lang, AV. Glukhov, E Grandi, and L. Eckhardt. Starting at the end to get back to the beginning: a proof-of-concept study to identify cellular arhythmic features of Idiopathic Ventricular Fibrillation from patient-derived iPSC-cardiomyocytes (Under Review)

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Peer-reviewed Journal Articles

1. Hellgren KT, Ni H, Morotti S, Grandi E. Predictive male-to-female translation of cardiac electrophysiological response to drugs. JACC: Clinical Electrophysiology. 2023. In press.

2. Herrera N, Zhang X, Ni H, Maleckar M, Heijman J, Dobrev D, Grandi E, Morotti S. Dual effects of the small-conductance Ca2+-activated K+ current on human atrial electrophysiology and Ca2+-driven arrhythmogenesis: an in silico study. American Journal of Physiology - Heart & Circulatory Physiology. 2023. In press

3. Bai J, Zhao J, Ni H, Yin D. Editorial: Diagnosis, monitoring, and treatment of heart rhythm: new insights and novel computational methods. Front. Physiol., August 2023. 10.3389/fphys.2023.1272377

4. Ni H, Morotti S, Zhang X, Dobrev D, Grandi E. Integrative human atrial modeling unravels interactive PKA and CaMKII signaling as key determinant of atrial arrhythmogenesis. Cardiovascular Research. 2023. 10.1093/cvr/cvad118

5. Kervadec A, Kezos J, Ni H, Yu M, Spiering S, Kannan S, Andersen P, Grandi E, Ocorr K, Colas AR. Multiplatform Modeling of Atrial Fibrillation Identifies Phospholamban as Central Regulator of Cardiac Rhythm. Disease Models & Mechanisms. 2023. 049962.

6. Bartolucci C, Ni H#. Calcium-directed feedback control of the sinoatrial node robustness. Biophysical Journal. 2023. 122(9):1571-1573. 10.1016/j.bpj.2023.03.040

7. Ding Y, Lang D, Yan J, Bu H, Li H, Jiao K, Yang J, Ni H, Morotti S, Le T, Clark KJ, Port J, Ekker SC, Cao H, Zhang Y, Wang J, Grandi E, Li Z, Shi Y, Li Y, Glukhov AV, Xu X. A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene. Elife. 2022 Oct 18;11:e77327.

8. X. Zhang, H. Ni, S. Morotti, D. Sato, WE. Louch, AG. Edwards, E. Grandi. Mechanisms of spontaneous Ca2+ release‐mediated arrhythmia in a novel 3D human atrial myocyte model: I. Transverse‐axial tubule variation. The Journal of Physiology. 2022. doi.org/10.1113/JP283363 (highlighted in journal editorial comments)

9. X. Zhang, C.E.R. Smith, S. Morotti, A.G. Edwards, D. Sato, W.E. Louch, H. Ni, E. Grandi. Mechanisms of spontaneous Ca2+ release-mediated arrhythmia in a novel 3D human atrial myocyte model: II. Ca2+ -handling protein variation. The Journal of Physiology, 16 Sep 2022, DOI: 10.1113/jp283602 (highlighted in journal editorial comments)

10. Y Wang, M Zhao, B Xu, S Bahriz, C Zhu, A Jovanovic, H Ni, A Jacobi, N Kaludercic, F Di Lisa, J Shih, N Paolocci, Y K. Xiang. X. Monoamine oxidase A and organic cation transporter 3 coordinate intracellular β1AR signaling to calibrate cardiac contractile function. Basic Res Cardiol. 2022 Jul 17;117(1):37.

11. Morotti S, Liu C, Hegyi B, Ni H, Fogli Iseppe A, Wang L, Ripplinger C, Bers D, Edwards A, Grandi E. Quantitative cross-species translators of cardiac myocyte electrophysiology: model training, experimental validation, and applications. Science Advances 7(47):eabg0927

12. Morotti S, Ni H, Peters CH, Rickert C, Asgari-Targhi A, Sato D, Glukhov AV, Proenza C, Grandi E. 2021. Intracellular Na+ Modulates Pacemaking Activity in Murine Sinoatrial Node Myocytes: An In Silico Analysis. International Journal of Molecular Sciences 22:5645. doi:10.3390/ijms22115645

13. Iseppe AF, Ni H, Zhu S, Zhang X, Coppini R, Yang P-C, Srivatsa U, Clancy CE, Edwards AG, Morotti S, Grandi E. 2021. Sex-Specific Classification of Drug-Induced Torsade de Pointes Susceptibility Using Cardiac Simulations and Machine Learning. Clinical Pharmacology & Therapeutics 110:380–391. doi:10.1002/cpt.2240

14. D’Souza A, Wang Y, Anderson C, Bucchi A, Baruscotti M, Olieslagers S, Mesirca P, Johnsen AB, Mastitskaya S, Ni H, Zhang Y, Black N, Cox C, Wegner S, Bano-Otalora B, Petit C, Gill E, Logantha SJRJ, Dobrzynski H, Ashton N, Hart G, Zhang R, Zhang H, Cartwright EJ, Wisloff U, Mangoni ME, da Costa Martins PA, Piggins HD, DiFrancesco D, Boyett MR. 2021. A circadian clock in the sinus node mediates day-night rhythms in Hcn4 and heart rate. Heart Rhythm 18:801–810. doi:10.1016/j.hrthm.2020.11.026

15. Ni H, Fogli Iseppe A, Giles WR, Narayan SM, Zhang H, Edwards AG, Morotti S, Grandi E. Populations of in silico myocytes and tissues reveal synergy of multi-atrial-predominant K+-current block in atrial fibrillation. British Journal of Pharmacology. 2020;177:4497–4515. doi: 10.1111/bph.15198

16. Clayton RH, Aboelkassem Y, Cantwell CD, Corrado C, Delhaas T, Huberts W, Lei C, Ni H, Panfilov A, Roney C and dos Santos R. An audit of uncertainty in multi-scale cardiac electrophysiology models. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences. 2020;378: 20190335. doi:10.1098/rsta.2019.0335

17. Z. Li, G.R. Mirams, T. Yoshinaga, B.J. Ridder, X. Han, J.E. Chen, N.L. Stockbridge, T.A. Wisialowski, B. Damiano, S. Severi, P. Morissette, P.R. Kowey, M. Holbrook, G. Smith, R.L. Rasmusson, M. Liu, Z. Song, Z. Qu, D.J. Leishman, J. Steidl‐Nichols, B. Rodriguez, A. Bueno‐Orovio, X. Zhou, E. Passini, A.G. Edwards, S. Morotti, H. Ni, E. Grandi, C.E. Clancy, J. Vandenberg, A. Hill, M. Nakamura, T. Singer, L. Polonchuk, A. Greiter‐Wilke, K. Wang, S. Nave, A. Fullerton, E.A. Sobie, M. Paci, F.M. Tshinanu, D.G. Strauss, General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy, Clinical Pharmacology & Therapeutics. 107 (2020) 102–111. https://doi.org/10.1002/cpt.1647.

18. Ni H, Zhang H, Grandi E, Narayan SM, Giles WR. Transient outward K+ current can strongly modulate action potential duration and initiate alternans in the human atrium. Am J Physiol Heart Circ Physiol. 2019 Mar 1;316(3):H527-H542. (Highlighted in a podcast discussion from AJP: https://ajpheart.podbean.com/e/k-channel-isoforms-regulate-human-atrial-arrhythmogenesis/)

19. Kara V, Ni H, Perez Alday EA, Zhang H. ECG Imaging to Detect the Site of Ventricular Ischemia Using Torso Electrodes: A Computational Study. Front Physiol. 2019;10:50.

20. Ni H, Morotti S, Grandi E. A Heart for Diversity: Simulating Variability in Cardiac Arrhythmia Research. Front Physiol. 2018;9:958.

21. Ni H, Rajamani S, Giles WR. Novel regulation of the mammalian cardiac Na+ channel by dipeptidyl peptidase 10 interactions: An editorial comment. Int J Cardiol. 2019 Jun 1;284:74-76.

22. Ni H, Narsingani K, Zhang H, Giles WR. Can principles of the surface potential be combined with knowledge of natural products to reduce atrial rhythm disturbances?. Acta Physiol (Oxf). 2018 Jan;222(1).

23. Wang W, Zhang S, Ni H, Garratt CJ, Boyett MR, Hancox JC, Zhang H. Mechanistic insight into spontaneous transition from cellular alternans to arrhythmia-A simulation study. PLoS Comput Biol. 2018 Nov;14(11):e1006594.

24. Whittaker DG, Colman MA, Ni H, Hancox JC, Zhang H. Human Atrial Arrhythmogenesis and Sinus Bradycardia in KCNQ1-Linked Short QT Syndrome: Insights From Computational Modelling. Front Physiol. 2018;9:1402.

25. Ni H, Whittaker DG, Wang W, Giles WR, Narayan SM, Zhang H. Synergistic Antiarrhythmic Effects in Human Atria with Combined Use of Sodium Blockers and Acacetin. Front Physiol. 2017;8:946.

26. Whittaker DG, Ni H, Benson AP, Hancox JC, Zhang H. Computational Analysis of the Mode of Action of Disopyramide and Quinidine on hERG-Linked Short QT Syndrome in Human Ventricles. Front Physiol. 2017;8:759.

27. Ni H, Adeniran I, Zhang H. In-silico investigations of the functional impact of KCNA5 mutations on atrial mechanical dynamics. J Mol Cell Cardiol. 2017 Oct;111:86-95.

28. Ni H*, Wang Y*, Crawford W, Zhang S, Cheng L, Zhang H, Lei M. Three-dimensional image reconstruction of distribution of Pnmt+ cell-derived cells in murine heart. Sci Data. 2017 Sep 26;4:170134. [*Co-first author]

29. Colman MA*, Ni H*, Liang B, Schmitt N, Zhang H. In silico assessment of genetic variation in KCNA5 reveals multiple mechanisms of human atrial arrhythmogenesis. PLoS Comput Biol. 2017 Jun;13(6):e1005587. [*Co-first author]

30. Brocklehurst P*, Ni H*, Zhang H, Ye J. Electro-mechanical dynamics of spiral waves in a discrete 2D model of human atrial tissue. PLoS One. 2017;12(5):e0176607. [*Co-first author]

31. Whittaker DG, Ni H, El Harchi A, Hancox JC, Zhang H. Atrial arrhythmogenicity of KCNJ2 mutations in short QT syndrome: Insights from virtual human atria. PLoS Comput Biol. 2017 Jun;13(6):e1005593.

32. Wang Y, Lin WK, Crawford W, Ni H, Bolton EL, Khan H, Shanks J, Bub G, Wang X, Paterson DJ, Zhang H, Galione A, Ebert SN, Terrar DA, Lei M. Optogenetic Control of Heart Rhythm by Selective Stimulation of Cardiomyocytes Derived from Pnmt+ Cells in Murine Heart. Sci Rep. 2017 Jan 13;7:40687.

33. Alday EA, Ni H, Zhang C, Colman MA, Gan Z, Zhang H. Comparison of Electric- and Magnetic-Cardiograms Produced by Myocardial Ischemia in Models of the Human Ventricle and Torso. PLoS One. 2016;11(8):e0160999.

34. Chen M, Ni H, Wang Z, Jiang Y. Research on the modelling of burr formation process in micro-ball end milling operation on Ti–6Al–4V. The International Journal of Advanced Manufacturing Technology. 2012;62(9-12):901–12.