24 April 2026
Apr. 2026. Our recent paper on sinoatrial node pacemaking and heart failure has been published in JACC: Clinical Electrophysiology and was highlighted by an accompanying editorial in the journal.
In this study, we combined experiments and computational analysis to show that caveolar compartmentalization is a key structural and signaling determinant of stable sinoatrial node rhythmicity, and that disruption of this organization contributes to sinus node dysfunction in heart failure. The work identifies caveolae and their associated signaling microdomains as an important component of cardiac pacemaker robustness and provides new mechanistic insight into how heart failure destabilizes normal rhythm generation.
We are especially pleased to see the paper recognized by an editorial in JACC: Clinical Electrophysiology, which underscores the broader significance of this work for cardiac electrophysiology and sinus node biology.